Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders
Clinical Psychopharmacology and Neuroscience
;
: 78-85, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-127842
ABSTRACT
OBJECTIVE:
We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.METHODS:
The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.RESULTS:
We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.CONCLUSION:
Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psicotrópicos
/
Antipsicóticos
/
Benzodiazepinas
/
Modelos Lineares
/
Clozapina
/
Polimedicação
/
Eletroencefalografia
/
Lítio
/
Anticonvulsivantes
/
Antidepressivos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2011
Tipo de documento:
Artigo
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