The effect of ONO-1078 (Pranlukast hydrate), a leukotriene-receptor antagonist, for the treatment of moderate to severe asthmatics with chronic rhinosinusitis / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 593-600, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-12807
ABSTRACT
BACKGROUND AND OBJECTIVE:
The cysteinyl leukotrienes are bioactive lipid mediators that contribute to the pathophysiologic condition of asthma and rhinosinusitis. We tested whether the leukotriene receptor antagonist ONO-1078 (Pranukast) had steroid sparing effect on mode- rate to severe asthmatics with chronic rhinosinusitis.METHODS:
Eighteen asthmatic patients with chronic rhinosinusitis who required more than 800 mcg/day of budesonide inhalation for the adequate control of asthma symptoms were recruited for this study. For the first 4 weeks, patients were treated with high dose (800-1200 mcg/day) budesonide inhalation. For the next 4 weeks, the dose of budesonide inhalation was decreased by 400 mcg/day and oral ONO-1078 (900mg/day) was administered. FEV1 was evaluated every 2 weeks, and PC20 on methacholine challenge, serum eosinophil cationic protein and blood eosinophil count were measured every 4 weeks. Diary cards were completed with morning and evening PEFR and symptom scores for asthma and rhinosinusitis during the treatment periods.RESULTS:
Despite the reduction of the dose of inhaled corticosteroid by 400mcg/day, FEV1 and PEFR did not decrease with the addition of oral ONO-1078. The symptom scores of asthma and rhino-sinusitis did not change, and the need for beta2-agonist did not increase.CONCLUSION:
These results suggest that ONO-1078 might have steroid sparing effect in moderate to severe persistent asthmatics with chronic rhinosinusitis who required high dose nhaled budesonide to control asthma symptoms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Pico do Fluxo Expiratório
/
Inalação
/
Leucotrienos
/
Cloreto de Metacolina
/
Receptores de Leucotrienos
/
Budesonida
/
Proteína Catiônica de Eosinófilo
/
Eosinófilos
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
2000
Tipo de documento:
Artigo
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