Your browser doesn't support javascript.
loading
Evaluation of the Urinary Glucose Tetrasaccharide Assay Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Diagnosis of Pompe Disease
Laboratory Medicine Online ; : 211-214, 2015.
Artigo em Coreano | WPRIM | ID: wpr-128364
ABSTRACT
We evaluated the urinary glucose tetrasaccharide (Glc4) assay using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The calibration curve was linear over a range of 5-500 micromol/L. Performance parameters such as intra- and inter-day imprecision CVs were 6.52-14.6% and 11.5-13.2%, respectively. The mean concentrations of urinary Glc4 in 27 normal controls and 3 pseudodeficiency patients were 1.5 and 12.1 mmol/mol creatinine, respectively. Urinary Glc4 concentration in a patient with Pompe disease was 171.3 mmol/mol creatinine, which decreased to 130.9 mmol/mol following enzyme replacement therapy. Based on our results, we suggest that the urinary Glc4 assay using UPLC-MS/MS can be a reliable diagnostic tool for identification of patients with Pompe disease.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Espectrometria de Massas / Calibragem / Doença de Depósito de Glicogênio Tipo II / Creatinina / Diagnóstico / Terapia de Reposição de Enzimas / Glucose Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2015 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Espectrometria de Massas / Calibragem / Doença de Depósito de Glicogênio Tipo II / Creatinina / Diagnóstico / Terapia de Reposição de Enzimas / Glucose Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Laboratory Medicine Online Ano de publicação: 2015 Tipo de documento: Artigo