Effect of a Combination of Nitric Oxide Donor with Prostaglandin El on Penile Erection in Rats / 대한비뇨기과학회지

ABSTRACT

PURPOSE: Nitric oxide(NO)-cyclic GMP pathway has a dominant role In penile erection over other neurotransmission pathway, which suggests that NO donor is a more physiologic and effective agent than others in the treatment of erectile dysfunction. However, the clinical efficacy of NO donor remains debatable. We investigated the effect of combination of NO donor with prostaglandin El(PGE1) on penile erection in the rat to predict its clinical utilization. MATERIALS AND METHODS: Intracavernous injection of PGE1 alone(10(-7)-10(-4)M) or NO donor alone(SIN-1, SNAP, SNP, 10(-7)-10(-3)M) induced penile erection in a dose dependent manner. RESULTS: Of those, SNP at high doses produced full erection, comparable to that induced by cavernous nerve stimulation. It also caused significant drop of systemic blood pressure. In combined injection of PGE1(5xl0-6M) with NO donor, every combination with SIN-1 , SNAP, or SNP enhanced penile erection all doses(10(-7)-10(-3)M). Of those, combined injection with low dose SNP was found to be most erective to produce penile erection without significant hypotension. CONCLUSIONS: The results suggest that intracavernous injection of combined NO donor, especially low dose SNP, with PGE1 will be effective in the treatment of erectile impotence, although it require clinical investigation.