A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
Diabetes & Metabolism Journal
;
: 106-112, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-128752
ABSTRACT
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially beta-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic beta-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and beta-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect beta-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with beta-cell failure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredução
/
Superóxido Dismutase
/
Sistemas do Segundo Mensageiro
/
Transdução de Sinais
/
Expressão Gênica
/
Coristoma
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Espécies Reativas de Nitrogênio
/
Complicações do Diabetes
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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