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The Infusion Rate of Mivacurium for Cesarean Section and its Spontaneous Recovery / 대한마취과학회지
Korean Journal of Anesthesiology ; : 198-205, 1996.
Artigo em Coreano | WPRIM | ID: wpr-128930
ABSTRACT

BACKGROUND:

Mivacurium is a nondepolarizing muscle relaxant and metabolized by pseudo-cholinesterase(pChe). Many reports show fall in pChe activity during pregnancy, so the metabolism of mivacurium may be delayed and muscle relaxation would be prolonged.

METHODS:

Muscle relaxation of full-term pregnant women(C group, n=10) and nopregnant women(Non-C group, n=10) was maintained by continuous infusion of mivacurium to keep 1st response of TOF at 5+/-1%. After discontinuance of infusion, recovery profiles were measured with accelerography.

RESULTS:

The Infusion rate of mivacurium to maintain 1st twich response of TOF at 5+/-1% was significantly low in C group comparing with Non-C group(P<0.05). There was no significant difference in pChe activity between two groups. There was no significant difference in recovery index, recovery time(T1 25%-T4 ratio, 0.75). There was a little correlation between the total infusion time and recovery profiles(recovery index r2=0.37, recovery time r2=0.28). Strong correlation existed between bolus-TS(time interval from the injection of mivacurium to recovery of 5% twitch hight) and infusion rate(r2=0.76).

CONCLUSION:

The mivacurium infusion rate of C group to maintain muscle relaxation was significantly lower than Non-C group. There would be many possible reasons including over-estimation of paturient body weight compared with lean body mass, decrease of blood volume due to hemorrhage.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Volume Sanguíneo / Peso Corporal / Butirilcolinesterase / Cesárea / Hemorragia / Metabolismo / Relaxamento Muscular / Obstetrícia Limite: Gravidez Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 1996 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Volume Sanguíneo / Peso Corporal / Butirilcolinesterase / Cesárea / Hemorragia / Metabolismo / Relaxamento Muscular / Obstetrícia Limite: Gravidez Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 1996 Tipo de documento: Artigo