Short-Term Outcome of Infliximab Therapy in Pediatric Crohn's Disease: A Single-Center Experience / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
; : 236-243, 2017.
Article
em En
| WPRIM
| ID: wpr-129001
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Studies on the efficacy of infliximab (IFX) in a large population of pediatric patients with Crohn's disease (CD) are limited, and prognostic factors are not well-known. The aim of this study was to evaluate outcomes of IFX in pediatric patients with CD and to identify factors associated with poor prognosis. METHODS: We retrospectively analyzed medical data of 594 pediatric patients with CD between 1987 and 2013 in a tertiary center. Of these, 156 children treated with IFX were enrolled and were followed up for at least a year with intact data. Outcomes of induction and maintenance, classified as failure or clinical response, were evaluated on the tenth and 54th week of IFX therapy. RESULTS: We treated 156 pediatric patients with CD with IFX, and the median duration of IFX therapy was 47 months. For IFX induction therapy, 134 (85.9%) patients experienced clinical response on the 10th week. Among the 134 patients who showed response to induction, 111 (82.8%) patients maintained the clinical response on the 54th week. In multivariate analysis, low hematocrit (p=0.046) at the time of IFX initiation was associated with the failure of IFX induction. For IFX maintenance therapy, longer duration from the initial diagnosis to IFX therapy (p=0.017) was associated with maintenance failure on the 54th week. CONCLUSION: We have shown the acceptable outcomes of IFX in a large cohort of pediatric CD patients in Korea. Hematocrit and early introduction of IFX may be prognostic factors for the outcomes of IFX.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Prognóstico
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Doença de Crohn
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Análise Multivariada
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Estudos Retrospectivos
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Estudos de Coortes
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Diagnóstico
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Infliximab
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Hematócrito
/
Coreia (Geográfico)
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pediatric Gastroenterology, Hepatology & Nutrition
Ano de publicação:
2017
Tipo de documento:
Article