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A Retrospective Analysis of Characteristics of Probiotics Associated with Invasive Bacterial Infections in Children
Pediatric Infection & Vaccine ; : 168-177, 2017.
Artigo em Coreano | WPRIM | ID: wpr-129034
ABSTRACT

PURPOSE:

The purpose of this study was to analyze the clinical features and risk factors of invasive infections caused by Lactobacillus spp. and Saccharomyces spp., components of commercially available probiotics.

METHODS:

We analyzed demographic and clinical data from children ≤18 years of age with an invasive infection caused by Lactobacillus spp. or Saccharomyces spp. at the Asan Medical Center Children's Hospital from January 1998 to June 2016. Probiotic consumption data were also analyzed.

RESULTS:

During the study period, a total of 24 episodes of invasive infections were caused by Lactobacillus spp. (n=16) and Saccharomyces cerevisiae (n=8). Along with the increase of probiotic use (755,594 [days/1,000 patient-admission days] in 2001 to 2005, 1,444,066 in 2006 to 2010, and 6,904,736 in 2011 to 2016), the incidence of probiotic-associated invasive infection increased (R2=0.70). The median age of the patients was 1.8 years (range, 2 months to 17 years), and most of them had underlying medical conditions. The 30-day mortality rate was 20.8% (5/24), and 11 (45.8%) of these patients resulted from a severe invasive infection. We determined the risk factors for invasive infection to be previous intensive care unit stay (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.5 to 6.1] and the presence of a central venous catheter (OR, 2.2; 95% CI, 1.2 to 4.3).

CONCLUSIONS:

Although the probiotic-associated invasive infections rarely occurred in children, the incidence has increased along with probiotic pressure. Judicious use of probiotics is mandatory, especially in young children with underlying medical conditions and continuous surveillance will be needed to minimize the safety concerns.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Saccharomyces / Saccharomyces cerevisiae / Infecções Bacterianas / Incidência / Estudos Retrospectivos / Fatores de Risco / Mortalidade / Probióticos / Cateteres Venosos Centrais / Unidades de Terapia Intensiva Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Pediatric Infection & Vaccine Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Saccharomyces / Saccharomyces cerevisiae / Infecções Bacterianas / Incidência / Estudos Retrospectivos / Fatores de Risco / Mortalidade / Probióticos / Cateteres Venosos Centrais / Unidades de Terapia Intensiva Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Pediatric Infection & Vaccine Ano de publicação: 2017 Tipo de documento: Artigo