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Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response
Biomolecules & Therapeutics ; : 383-389, 2017.
Artigo em Inglês | WPRIM | ID: wpr-129206
ABSTRACT
Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action and potential mechanisms of dexmedetomidine against ischemia-reperfusion induced cerebral injury. Transient focal cerebral ischemia-reperfusion injury was induced in Sprague-Dawley rats by middle cerebral artery occlusion. After the ischemic insult, animals then received intravenous dexmedetomidine of 1 μg/kg load dose, followed by 0.05 μg/kg/min infusion for 2 h. After 24 h of reperfusion, neurological function, brain edema, and the morphology of the hippocampal CA1 region were evaluated. The levels and mRNA expressions of interleukin-1β, interleukin-6 and tumor nevrosis factor-α as well as the protein expression of inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-κBp65, inhibitor of κBα and phosphorylated of κBα in hippocampus were assessed. We found that dexmedetomidine reduced focal cerebral ischemia-reperfusion injury in rats by inhibiting the expression and release of inflammatory cytokines and mediators. Inhibition of the nuclear factor-κB pathway may be a mechanism underlying the neuroprotective action of dexmedetomidine against focal cerebral I/R injury.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Edema Encefálico / RNA Mensageiro / Reperfusão / Traumatismo por Reperfusão / Citocinas / Interleucina-6 / Ratos Sprague-Dawley / Infarto da Artéria Cerebral Média / Dexmedetomidina / Ciclo-Oxigenase 2 Limite: Animais Idioma: Inglês Revista: Biomolecules & Therapeutics Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Edema Encefálico / RNA Mensageiro / Reperfusão / Traumatismo por Reperfusão / Citocinas / Interleucina-6 / Ratos Sprague-Dawley / Infarto da Artéria Cerebral Média / Dexmedetomidina / Ciclo-Oxigenase 2 Limite: Animais Idioma: Inglês Revista: Biomolecules & Therapeutics Ano de publicação: 2017 Tipo de documento: Artigo