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Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 192-196, 2013.
Artigo em Inglês | WPRIM | ID: wpr-129698
ABSTRACT

BACKGROUND:

This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS AND

METHODS:

The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression.

RESULTS:

The mean serum CEA and Cyfra 21-1 levels prior to surgery were 6.8+/-23.1 mg/dL (range, 0.01 to 390.8 mg/dL) and 5.4+/-12.3 mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1 beta=8.463, p=0.010) and N stage (N2/3 vs. N0 beta=9.208, p<0.001) and histology (adenocarcinoma vs. squamous cell beta=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (beta=2.579, p<0.001) and histology (squamous cell vs. adenocarcinoma beta=4.420, p=0.020).

CONCLUSION:

Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Antígeno Carcinoembrionário / Modelos Lineares / Carcinoma Pulmonar de Células não Pequenas / Queratina-19 / Queratinas / Neoplasias Pulmonares / Linfonodos / Antígenos de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Antígeno Carcinoembrionário / Modelos Lineares / Carcinoma Pulmonar de Células não Pequenas / Queratina-19 / Queratinas / Neoplasias Pulmonares / Linfonodos / Antígenos de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2013 Tipo de documento: Artigo