Brain MRI Findings of Neuropsychiatric Lupus
Journal of the Korean Radiological Society
;
: 657-661, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-129834
ABSTRACT
PURPOSE:
To evaluate the brain MRI findings in patients with neuropsychiatric lupus. MATERIALS ANDMETHODS:
In 26 patients (MF=224; aged 9 -48 years) in whom the presence of systemic lupus erythematosus was clinically or pathologically proven and in whom neuropsychiatric lupus was also clinically diagnosed, the findings of brain MRI were retrospectively evaluated. MR images were analyzed with regard to the distribution, location, size and number of lesions due to cerebral ischemia or infarction, the presence of cerebral atrophy, and the extent and degree of brain parenchymal and intravascular enhancement.RESULTS:
The most common MRI findings were lesions due to cerebral ischemia or infarction occurring in 18 patients (69%), and located within deep periventricular white matter (n=10), subcortical white matter (n=8), the cerebral cortex (n=7), basal ganglia (n=7), or brain stem or cerebellum (n=2). The lesions were single (n=3) or multiple (n=15), and in 17 patients were less than 1 cm in diameter in regions other than the cerebral cortex. In six of these patients, lesions of 1 -4 cm in diameter in this region were combined, and one occurred in the cerebral cortex only. Cerebral atrophy was seen in 16 patients (62%), in ten of whom there was no past history of treatment with steroids for more than six months. In 15 patients (58%), contrast-enhanced MR image revealed diffuse enhancement of the basal ganglia or intravascular enhancement. In no case were MRI findings normal.CONCLUSION:
The primary manifestations of neuropsychiatric lupus are multifocal ischemia or infarctions in the cerebral cortex, and subcortical and deep white matter, and the cerebral atrophy. Contrast-enhanced MR images also demonstrated diffuse enhancement of the basal ganglia and intravascular enhancement, both thought to be related to the congestion due to the stagnation of cerebral blood flow.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Atrofia
/
Esteroides
/
Gânglios da Base
/
Encéfalo
/
Tronco Encefálico
/
Imageamento por Ressonância Magnética
/
Cerebelo
/
Córtex Cerebral
/
Isquemia Encefálica
/
Estudos Retrospectivos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Radiological Society
Ano de publicação:
2000
Tipo de documento:
Artigo
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