Overexpression of hTERT and c-erbB-2 are correlated in ovarian epithelial cancer / 부인종양
Korean Journal of Gynecologic Oncology
;
: 142-146, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-129885
ABSTRACT
OBJECTIVE:
It is still unclear how the abnormal hTERT expression is involved in the process of ovarian carcinogenesis. A recent report demonstrated that the introduction of c-erbB-2 could efficiently induce tumorigenicity of cells with the transfection of SV40 large T antigen and hTERT. It is designed to find correlation between overexpression of hTERT and c-erbB-2 in ovarian carcinogenesis.METHODS:
Using immunohistochemistry, we tested whether overexpression of hTERT and c-erbB-2 were associated in ovarian cancer. Immunohistochemical staining of hTERT and c-erbB-2 was done in 63 cases of ovarian cancer. Overexpression of hTERT and c-erbB-2 were correlated to clinicopathological variables.RESULTS:
Overexpression of hTERT was found in 7 (11.1%) of cases, whereas overexpression of c-erbB2 was founded in 3 (4.8%) of cases. It was found that overexpression of hTERT and c-erbB-2 were significantly correlated (p=0.03). Neither overexpression of hTERT nor that of c-erbB-2 was associated with any of clinicopathological variables, such as stage, grade, and histology.CONCLUSION:
Although the significant correlation between hTERT and c-erbB-2 was found, the low frequency of overexpression of hTERT and c-erbB-2 suggests that cooperation of hTERT and c-erbB-2 may be minor mechanism of ovarian carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Imuno-Histoquímica
/
Transfecção
/
Receptor ErbB-2
/
Carcinogênese
/
Antígenos Virais de Tumores
Idioma:
Inglês
Revista:
Korean Journal of Gynecologic Oncology
Ano de publicação:
2006
Tipo de documento:
Artigo
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