Anti-p200 Pemphigoid / 대한피부과학회지
Korean Journal of Dermatology
;
: 912-916, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-130070
ABSTRACT
Anti-p200 pemphigoid is an autoimmune subepidermal bullous disease characterized by circulating and tissue-bound autoantibodies directed against a 200 kD protein of the human dermis. We report a 78-year-old male who was presented with bullous eruptions on the trunk, extremities, which clinically resemble bullous pemphigoid, epidermolysis bullosa aquisita, linear IgA dermatosis or dermatitis herpetiformis. Oral muscosa of the lower lip was also affected. Histopathological examination of a skin biopsy specimen from the trunk revealed subepidermal blister and infiltration predominantly by neutrophils. Direct immunofluorescence revealed linear deposits of IgG, C3 and IgA at the basement membrane zone. Indirect immunofluorescence using salt-split skin showed that IgG antibodies bound on the dermal side. Immunoblotting with dermal extracts showed that the patient's IgG autoantibodies reacted with a 200 kD protein. The patient showed good response to dapsone.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Autoanticorpos
/
Membrana Basal
/
Biópsia
/
Imunoglobulina A
/
Imunoglobulina G
/
Immunoblotting
/
Vesícula
/
Dermatite Herpetiforme
/
Epidermólise Bolhosa
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2012
Tipo de documento:
Artigo
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