Refocusing Peroxisome Proliferator Activated Receptor-alpha: A New Insight for Therapeutic Roles in Diabetes
Diabetes & Metabolism Journal
;
: 326-332, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-130795
ABSTRACT
Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-alpha (PPAR-alpha) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-alpha, summarize data from clinical studies on the effect of PPAR-alpha agonist in diabetes, and will discuss the possible therapeutic role of PPAR-alpha activation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Cardiovasculares
/
Complicações do Diabetes
/
PPAR alfa
/
Ácidos Fíbricos
/
Homeostase
/
Inflamação
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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