Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
Yonsei Medical Journal
;
: 354-358, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-130808
ABSTRACT
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in cultured fetal astrocytes. In particular, IFN-gammainduced the highest levels of TRAIL in cultured astrocytes. When astrocytes were pre-reated with IFN-gamma they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-gamma modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicoproteínas de Membrana
/
Células Cultivadas
/
Astrócitos
/
Interferon gama
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
Proteínas Reguladoras de Apoptose
/
Ligante Indutor de Apoptose Relacionado a TNF
/
Antineoplásicos
Limite:
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2006
Tipo de documento:
Artigo
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