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Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
Immune Network ; : 288-298, 2011.
Article em En | WPRIM | ID: wpr-131308
Biblioteca responsável: WPRO
ABSTRACT
BACKGROUND: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. METHODS: The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, and NO, on anti-inflammatory cytokines including IL-4, IL-10, TGF-beta, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages. RESULTS: ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and 11beta-HSD1. CONCLUSION: These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.
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Texto completo: 1 Índice: WPRIM Assunto principal: Regulação para Baixo / Citocinas / Fator de Crescimento Transformador beta / Interleucina-4 / Interleucina-6 / Fator de Necrose Tumoral alfa / Interleucina-10 / Quimiocina CCL5 / Quimiocinas / Salvia Idioma: En Revista: Immune Network Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Regulação para Baixo / Citocinas / Fator de Crescimento Transformador beta / Interleucina-4 / Interleucina-6 / Fator de Necrose Tumoral alfa / Interleucina-10 / Quimiocina CCL5 / Quimiocinas / Salvia Idioma: En Revista: Immune Network Ano de publicação: 2011 Tipo de documento: Article