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The Clinical Features and Prognosis of Leukemia in Down Syndrome / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology ; : 186-192, 2002.
Artigo em Coreano | WPRIM | ID: wpr-13140
ABSTRACT

PURPOSE:

There are several reports that the risk of development of leukemias is much higher in Down syndrome (DS) children than in non DS children. But there are a few reports about the clinical features of leukemia in Down syndrome and the prognosis in Korea. The object of this study is to evaluate clinical features, treatment results and the prognosis of leukemia of Down syndrome patients.

METHODS:

We conducted retrospective reviews in 10 children with leukemia of Down syndrome who were admitted to the Department of Pediatrics in Yonsei University Hospital between March 1986 and December 2000. We analyzed the clinical features, laboratory findings and survival rates.

RESULTS:

A male to female ratio was 11.25. Median age at diagnosis was 2 years 8 months. Initial symptoms were hepatosplenomegaly, petechiae, fever and upper respiratory infection symptoms. The number of patients by the type was as followedacute myeloid leukemia (AML) 7 (70%), acute lymphocytic leukemia 2 (20%), acute mixed lineage leukemia 1 (10%). There were 4 cases of M7 subtype in AML. The median peripheral blood cell counts were as followed; leukocyte was 41,000/muL, hemoglobin was 8.7 g/dL, the platelet was 103,000/muL. The five years event free survival rate after diagnosis was 87.5% (7/8). The one patient relapsed and another one patient died of cardiac anomaly.

CONCLUSION:

There seemed to be several differences of clinical features between DS leukemia and non DS leukemia, especially prognosis. Multi-centered well organized study should be done to confirm our observation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pediatria / Prognóstico / Púrpura / Contagem de Células Sanguíneas / Plaquetas / Cromossomos Humanos Par 21 / Leucemia Mieloide Aguda / Leucemia / Leucemia Mieloide / Taxa de Sobrevida Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Pediatric Hematology-Oncology Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pediatria / Prognóstico / Púrpura / Contagem de Células Sanguíneas / Plaquetas / Cromossomos Humanos Par 21 / Leucemia Mieloide Aguda / Leucemia / Leucemia Mieloide / Taxa de Sobrevida Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Pediatric Hematology-Oncology Ano de publicação: 2002 Tipo de documento: Artigo