The Clinical Effect of Amniotic Membrane Transplantation for Various Ocular Surface Diseases

ABSTRACT

PURPOSE: To describe the clinical outcome of amniotic membrane transplantation(AMT) for various ocular surface diseases. METHODS: We reviewed the medical records of 52 eyes from 46 patients which had underwent AMT for various ocular surface diseases. We scored each eyes from 0 to 4 for subjective symptoms (symptom score) and epithelial healing (epithelial grade) at three months after AMT. The clinical score was calculated as the symptom score time the epithelial grade. RESULTS: The mean clinical score among all ocular surface disease was 10.41+/-4.26. The mean clinical scores for each disease are as follows 7.71+/-3.56 for corneal ulcers, 14.43+/-3.1 for persistent epithelial defects, 12.83+/-2.71 for exposure keratitis, 12.86+/-3.18 for herpes keratitis, 5.85+/-2.5 for bullous keratopathy, 10.53+/-4.27 for chemical corneal burns and 16.0+/-0.0 for shield ulcers. Subjective symptoms subsides and epithelial healing progressed in all patients treated by AMT. No complications occurred. CONCLUSIONS: AMT is an effective method for treating various ocular surface diseases, because AMT improves the subjective symptoms of patients and promotes the healing of epithelial lesions.