Dose-Dependent Effects of Evening Primrose Oil in Children and Adolescents with Atopic Dermatitis
Annals of Dermatology
;
: 285-291, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-131890
ABSTRACT
BACKGROUND:
Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined.OBJECTIVE:
The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids.METHODS:
Forty AD patients were enrolled for the study and randomly divided into 2 groups those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 0 (palmitic), C18 2n (linoleic), C18 3n (linolenic) and C20 4 (arachidonic acid) using gas chromatography.RESULTS:
The serum fatty acid levels C18 3n and C20 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups.CONCLUSION:
The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Óleos de Plantas
/
Ácidos Linoleicos
/
Oenothera biennis
/
Ácido gama-Linolênico
/
Dermatite Atópica
/
Eczema
/
Ácidos Graxos
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2013
Tipo de documento:
Artigo
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