Diabetic Ketoacidosis in a Patient with Acromegaly / 대한내분비학회지
Journal of Korean Society of Endocrinology
; : 393-398, 2004.
Article
em Ko
| WPRIM
| ID: wpr-131916
Biblioteca responsável:
WPRO
ABSTRACT
Acromegaly is a chronic, debilitating condition caused by excessive secretion of growth hormone (GH). Impaired glucose tolerance is present in about 20-40% of acromegaly, with diabetes mellitus developing in about 10~15% of patients, but diabetic ketoacidosis is a rare association. Herein is reported a case of diabetic ketoacidosis in a 33 year-old female, with a 4 year history of typical acromegaly features. She presented with severe hyperglycemia and ketoacidosis, but with no other cause for this metabolic derangement. She had elevated plasma GH (50 ng/mL) and IGF-1 (1533 ng/mL) levels, and a pituitary macroadenoma. About 200 units of insulin per day were required for her glycemic control. However, the serum IGF-1 level and daily insulin requirement were significantly tapered after a transsphenoidal adenomectomy and long acting somatostatin analogue treatment. There was a good correlation with the daily insulin requirement and plasma IGF-1 level. This case demonstrates that severe GH excess can cause diabetic ketoacidosis, and that its successful treatment improves glucose metabolism.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasma
/
Acromegalia
/
Resistência à Insulina
/
Fator de Crescimento Insulin-Like I
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Somatostatina
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Hormônio do Crescimento
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Cetoacidose Diabética
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Diabetes Mellitus
/
Glucose
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Hiperglicemia
Limite:
Adult
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Female
/
Humans
Idioma:
Ko
Revista:
Journal of Korean Society of Endocrinology
Ano de publicação:
2004
Tipo de documento:
Article