A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin / 대한피부과학회지
Korean Journal of Dermatology
;
: 940-944, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-131961
ABSTRACT
Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of TEN have not yet been identified. Recently, several reports suggested that apoptosis in TEN is promoted by proteins such as Fas antigen and high dose intravenous immunoglobulin(IVIG) inhibits Fas-mediated cell death by blocking the Fas receptor. We report a case of TEN in a 26-year-old woman who had been treated with prednisolone due to iritis. She was treated with high dose IVIG(0.4g/Kg/day for 4 days one day and 0.7g/Kg/day for consecutive). In our case, the progression of skin lesion was interrupted after IVIG infusion and favorable vital outcome was achieved with mild adverse effects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Imunoglobulinas
/
Prednisolona
/
Irite
/
Síndrome de Stevens-Johnson
/
Imunoglobulinas Intravenosas
/
Morte Celular
/
Apoptose
/
Receptor fas
/
Epiderme
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2000
Tipo de documento:
Artigo
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