Longitudinal Evaluation of Lung Function Associated with Emphysema in Healthy Smokers / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 177-183, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-132184
ABSTRACT
BACKGROUND:
Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers.METHODS:
One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months' time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed.RESULTS:
Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p<0.001). FEV1/FVC and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, FEV1/FVC and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010).CONCLUSION:
Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumaça
/
Espirometria
/
Tórax
/
Fumar
/
Tomografia Computadorizada por Raios X
/
Programas de Rastreamento
/
Prevalência
/
Enfisema
/
Pulmão
/
Pneumopatias
Tipo de estudo:
Estudo de prevalência
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2010
Tipo de documento:
Artigo
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