Tumor Necrosis Factor Alpha Blocker-Induced Erythrodermic Sarcoidosis in with Juvenile Rheumatoid Arthritis: A Case Report and Review of the Literature
Annals of Dermatology
; : 74-78, 2017.
Article
em En
| WPRIM
| ID: wpr-132710
Biblioteca responsável:
WPRO
ABSTRACT
The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy and review previous studies of cutaneous sarcoidosis. A 6-year-old Korean girl who had been suffering from juvenile rheumatoid arthritis presented with generalized erythematous skin eruption involving more than about 90% of her body surface area. After 14 months of etanercept treatment, the new erythematous skin eruption had developed and progressed into generalized erythroderma. Exclusion of suspected co-medication had been performed based on medication history. She had no other systemic symptoms, and ophthalmologic and neurologic examinations were normal. Histopathologic findings of the skin lesion revealed diffuse non-caseating granulomatous infiltrates composed of epithelioid histiocytes with sparse lymphocytes involving the entire dermis. Periodic-acid-Schiff and acid-fast stains were negative, and acid-fast bacilli was not detected by polymerase chain reaction of the skin biopsy. Based on clinicopathologic findings, she was diagnosed with etanercept-induced sarcoidal granuloma. After discontinuation of the suspected agent, the lesions spontaneously disappeared.
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Índice:
WPRIM
Assunto principal:
Artrite Juvenil
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Sarcoidose
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Pele
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Biópsia
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Superfície Corporal
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Linfócitos
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Reação em Cadeia da Polimerase
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Fator de Necrose Tumoral alfa
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Dermatite Esfoliativa
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Derme
Limite:
Child
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Female
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Humans
Idioma:
En
Revista:
Annals of Dermatology
Ano de publicação:
2017
Tipo de documento:
Article