Antibacterial Activity of Sanguisorba officinalis against Helicobacter pylori / 한국실험동물학회지
Laboratory Animal Research
;
: 257-263, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-133081
ABSTRACT
In this study, a medicinal herbal plant, Sanguisorba officinalis, was examined and screened for anti-Helicobacter pylori (H. pylori) activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Sanguisorba officinalis extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Sanguisorba officinalis extract demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Sanguisorba officinalis extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Sanguisorba officinalis extract. It could be a promising candidate herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas
/
Plantas Medicinais
/
Úlcera Gástrica
/
Urease
/
Programas de Rastreamento
/
Helicobacter pylori
/
Gerbillinae
/
Helicobacter
/
Sanguisorba
/
Etanol
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Laboratory Animal Research
Ano de publicação:
2010
Tipo de documento:
Artigo
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