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Inhibitory Effects of Korean Red Ginseng Extract on Atopic Dermatitis in NC/Nga Mice / 한국실험동물학회지
Laboratory Animal Research ; : 265-271, 2010.
Artigo em Coreano | WPRIM | ID: wpr-133082
ABSTRACT
Atopic dermatitis (AD) is a chronic eczematous skin disease attended by pruritus, erythema, edema, excoriation, and dryness. This study was to evaluate the effects of Korean red ginseng (RG) on AD in NC/Nga mice treated with 1-chloro-2,4,6-trinitrobenzene (picryl chloride; PC). Experimental groups were divided into 4 groups; normal control (NC), PC control, and PC-RG (50 and 100 mg/kg). RG was orally administered every day repeatedly during 6 weeks. The skin lesions in severity score, scratching behavior, serum immunoglobulin E (IgE), interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) levels, and histological appearance were examined. AD-like lesions were developed on the NC/Nga mice by topical PC applications. Oral administration of RG (50 and 100 mg/kg) significantly suppressed the development of AD, as analyzed by a modified SCORAD score. The scratching behavior decreased after RG administration. The levels of serum IgE, IL-4 and IFN-gamma were increased by PC stimulation, but treatment with RG (100 mg/kg) suppressed the increment of the serum IgE, IL-4 and IFN-gamma levels. Histologically, RG inhibited dermatitis lesions such as hypertrophy, hyperkeratosis, and infiltration of inflammatory cells into epidermis and dermis. These results suggest that the administration of RG may be effective in alleviating the AD induced by PC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cloreto de Picrila / Prurido / Pele / Imunoglobulina E / Imunoglobulinas / Administração Oral / Interleucina-4 / Interferon gama / Dermatopatias Eczematosas / Derme Limite: Animais Idioma: Coreano Revista: Laboratory Animal Research Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cloreto de Picrila / Prurido / Pele / Imunoglobulina E / Imunoglobulinas / Administração Oral / Interleucina-4 / Interferon gama / Dermatopatias Eczematosas / Derme Limite: Animais Idioma: Coreano Revista: Laboratory Animal Research Ano de publicação: 2010 Tipo de documento: Artigo