Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 42-46, 2011.
Article
em En
| WPRIM
| ID: wpr-133470
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). METHODS: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values. RESULTS: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000). CONCLUSION: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Síndrome do Ovário Policístico
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Testosterona
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Doenças Uterinas
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Biópsia
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Resistência à Insulina
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Índice de Massa Corporal
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Incidência
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Curva ROC
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Sensibilidade e Especificidade
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Jejum
Tipo de estudo:
Diagnostic_studies
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Incidence_studies
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Prognostic_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Clinical and Experimental Reproductive Medicine
Ano de publicação:
2011
Tipo de documento:
Article