Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: S141-S149, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-134027
ABSTRACT
PURPOSE:
Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice.METHODS:
The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks.RESULTS:
Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn.CONCLUSIONS:
Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity-associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Tirosina Quinases
/
Western Blotting
/
Imunofluorescência
/
Ritmo Circadiano
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
Fator Neurotrófico Derivado do Encéfalo
/
Proteína GAP-43
/
Proteína 1 de Resposta de Crescimento Precoce
/
Teste de Esforço
/
Neurogênese
Limite:
Animais
Idioma:
Inglês
Revista:
International Neurourology Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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