Decreased Serum Brain-Derived Neurotrophic Factor Levels in Elderly Korean with Dementia
Psychiatry Investigation
;
: 299-305, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-134175
ABSTRACT
OBJECTIVE:
The primary purpose of this study was to investigate the differences in the serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia.METHODS:
171 individuals over 65 years were enrolled in this study. Screening for cognitive impairments was carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) of the mean MMSE-KC score, and these were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease, Korean version (CERAD-K) and the Geriatric Depression Scale (GDS). The Clinical Dementia Rating Scale (CDRS) and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnostic criteria were used for further evaluation. Subjects with a CDRS score of 1 or higher were classified as having Alzheimer's disease (AD), and subjects with a CDRS score of 0.5 were classified as having a mild cognitive impairment (MCI). Subjects with a CDRS score of 0 were classified as having aging-associated cognitive decline (AACD). Serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method.RESULTS:
The serum BDNF levels were significantly lower in the subjects with MCI and AD compared with the healthy controls (p<0.01). A significant correlation was found between the total MMSE-KC score and serum BDNF level (r=0.295; p<0.01). However, no significant correlation was observed between the severity of MMSE-KC and the total GDS score. A significant difference was found in the total score of GDS between the AACD group and subjects with AD (p<0.05).CONCLUSION:
This study suggested that BDNF might be involved in the pathophysiology of cognitive decline in elderly people.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ensaio de Imunoadsorção Enzimática
/
Programas de Rastreamento
/
Fator Neurotrófico Derivado do Encéfalo
/
Demência
/
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Desoxicitidina
/
Depressão
/
Doença de Alzheimer
/
Disfunção Cognitiva
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2009
Tipo de documento:
Artigo
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