Pulmonary Adenocarcinoma with Heterotopic Ossification
Journal of Korean Medical Science
;
: 504-510, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-134336
ABSTRACT
Pulmonary adenocarcinoma is a common malignancy that often involves calcification; however, bone formation in primary lung adenocarcinoma is extremely rare. In ten cases of primary pulmonary adenocarcinoma with heterotopic ossification, we detected immunoreactivity against TGF-beta1, osteopontin, osteocalcin and Runx2 in the fibroblastic stroma and tumor cells within the area of ossification. Our results suggest that in primary pulmonary adenocarcinoma, heterotopic ossification occurs via intramembranous bone formation. To our knowledge, only 11 other cases of pulmonary adenocarcinoma with heterotopic ossification have been reported. Here, we present ten cases of pulmonary adenocarcinoma showing heterotopic ossification with a description of previously published results and the histogenesis of heterotopic bone formation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Adenocarcinoma
/
Tomografia Computadorizada por Raios X
/
Osteocalcina
/
Ossificação Heterotópica
/
Subunidade alfa 1 de Fator de Ligação ao Core
/
Osteopontina
/
Fator de Crescimento Transformador beta1
/
Neoplasias Pulmonares
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2009
Tipo de documento:
Artigo
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