Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
Journal of Korean Medical Science
;
: 979-982, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-134502
ABSTRACT
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Análise Mutacional de DNA
/
Biomarcadores
/
Testes Genéticos
/
Prevalência
/
Fatores de Risco
/
Bacteriemia
/
Medição de Risco
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Receptor 2 Toll-Like
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2006
Tipo de documento:
Artigo
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