The DPE, a core promoter element for transcription by RNA polymerase II
Experimental & Molecular Medicine
;
: 259-264, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-134601
ABSTRACT
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of action of all of the factors and coregulators that control the transcriptional activity of every gene. In this review, I describe our current knowledge of a downstream core promoter element termed the DPE, which is a TFIID recognition site that is conserved from Drosophila to humans. The DPE is located from +28 to +32 relative to the +1 transcription start site, and is mainly present in core promoters that lack a TATA box motif. Moreover, in Drosophila, the DPE appears to be about as common as the TATA box. There are distinct mechanisms of basal transcription from DPE- versus TATA-dependent core promoters. For instance, NC2/Dr1-Drap1 is a repressor of TATA-dependent transcription and an activator of DPE-dependent transcription. In addition, DPE-specific and TATA-specific transcriptional enhancers have been identified. These findings further indicate that the core promoter is an active participant in the regulation of eukaryotic gene expression.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Transcrição Gênica
/
RNA Polimerase II
/
Sequência de Bases
/
Regulação da Expressão Gênica
/
Elementos Facilitadores Genéticos
/
Regiões Promotoras Genéticas
/
Retroalimentação Fisiológica
/
Proteínas de Ligação a DNA
/
Modelos Genéticos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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