A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia
Journal of the Korean Society of Neonatology
; : 266-269, 2010.
Article
em En
| WPRIM
| ID: wpr-134720
Biblioteca responsável:
WPRO
ABSTRACT
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population has Gilbert's syndrome. Commonly, Gilbert's syndrome causes mild symptoms. However, a case of Gilbert's syndrome with severe neonatal hyperbilirubinemia is presented here. The patient developed jaundice three days after birth. Five days after birth, the patient's total serum bilirubin level was 34 mg/dL. The patient received intensive phototherapy and was given oral phenobarbital. Hemolytic hyperbilirubinemia was excluded on the basis of laboratory tests. Heterozygote polymorphisms of the promoter region (-3279T>G) and exon 1 (211G>A) were found in UGT1A1 gene. After discharge, the patient did not require any further treatment. This is the first case of proven Gilbert's syndrome with severe neonatal hyperbilirubinemia in Korea.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenobarbital
/
Fototerapia
/
Difosfato de Uridina
/
Bilirrubina
/
Éxons
/
Regiões Promotoras Genéticas
/
Glucuronosiltransferase
/
Parto
/
Hiperbilirrubinemia Neonatal
/
Doença de Gilbert
Limite:
Humans
/
Newborn
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of the Korean Society of Neonatology
Ano de publicação:
2010
Tipo de documento:
Article