Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs
Journal of Periodontal & Implant Science
;
: 50-58, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-135239
ABSTRACT
PURPOSE:
This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model.METHODS:
A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4x4x5 mm (buccolingual widthxmesiodistal widthxdepth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations.RESULTS:
Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone.CONCLUSIONS:
In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Doenças Periodontais
/
Polímeros
/
Poríferos
/
Pós
/
Regeneração
/
Dente Pré-Molar
/
Substitutos Ósseos
/
Transplantes
/
Engenharia Tecidual
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Periodontal & Implant Science
Ano de publicação:
2012
Tipo de documento:
Artigo
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