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A Phase II Study of Additional Four-Week Chemotherapy With Capecitabine During the Resting Periods After Six-Week Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer
Annals of Coloproctology ; : 192-197, 2013.
Artigo em Inglês | WPRIM | ID: wpr-135305
ABSTRACT

PURPOSE:

The aim of this study is to evaluate the efficacy and the safety of additional 4-week chemotherapy with capecitabine during the resting periods after a 6-week neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer.

METHODS:

Radiotherapy was delivered to the whole pelvis at a total dose of 50.4 Gy for 6 weeks. Oral capecitabine was administered at a dose of 825 mg/m2 twice daily for 10 weeks. Surgery was performed 2-4 weeks following the completion of chemotherapy.

RESULTS:

Between January 2010 and September 2011, 44 patients were enrolled. Forty-three patients underwent surgery, and 41 patients completed the scheduled treatment. Pathologic complete remission (pCR) was noted in 9 patients (20.9%). T down-staging and N down-staging were observed in 32 patients (74.4%) and 33 patients (76.7%), respectively. Grade 3 to 5 toxicity was noted in 5 patients (11.4%). The pCR rate was similar with the pCR rates obtained after conventional NCRT at our institute and at other institutes.

CONCLUSION:

This study showed that additional 4-week chemotherapy with capecitabine during the resting periods after 6-week NCRT was safe, but it was no more effective than conventional NCRT.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pelve / Neoplasias Retais / Reação em Cadeia da Polimerase / Terapia Neoadjuvante / Desoxicitidina / Tratamento Farmacológico / Quimiorradioterapia / Capecitabina / Fluoruracila Limite: Humanos Idioma: Inglês Revista: Annals of Coloproctology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pelve / Neoplasias Retais / Reação em Cadeia da Polimerase / Terapia Neoadjuvante / Desoxicitidina / Tratamento Farmacológico / Quimiorradioterapia / Capecitabina / Fluoruracila Limite: Humanos Idioma: Inglês Revista: Annals of Coloproctology Ano de publicação: 2013 Tipo de documento: Artigo