Detailed Characterization of Chromosomal Breakpoints in an ALL, L3 using Cross Species Color Banding / 대한임상병리학회지
Korean Journal of Clinical Pathology
; : 516-519, 2000.
Article
em Ko
| WPRIM
| ID: wpr-135676
Biblioteca responsável:
WPRO
ABSTRACT
Karyotype analysis by G-anding is the standard method for identifying numerical and structural chromosomal aberrations in cytogenetic laboratories. However, the origins of marker chromosomes, subtle translocations, or complex chromosomal rearrangements are often difficult to identify with certainty. Cross-pecies color banding is a new FISH-ased screening technique that enables the generation of a specific color banding pattern for each human chromosome based on the genomic homologies between man and various species of apes. We report application of Cross-pecies color banding (RxFISH) to characterize the chromosomal rearrangements of one leukemia sample the G-and karyotype of which were incomplete. The combination of G-anding and RxFISH in this case study yielded additional information beyond that obtained by either technique used alone in determining the precise breakpoints in complex chromosomal rearrangements.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Hominidae
/
Leucemia
/
Programas de Rastreamento
/
Aberrações Cromossômicas
/
Cromossomos Humanos
/
Citogenética
/
Cariótipo
Tipo de estudo:
Screening_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Clinical Pathology
Ano de publicação:
2000
Tipo de documento:
Article