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Change of peroxisome proliferator-activated receptor gamma expression pattern in the gerbil dentate gyrus after transient global cerebral ischemia / 대한해부학회지
Anatomy & Cell Biology ; : 111-116, 2014.
Artigo em Inglês | WPRIM | ID: wpr-137036
ABSTRACT
Peroxisome proliferator-activated receptor gamma (PPARgamma) has various actions including the regulation of adipocyte differentiation, lipid metabolism and glucose homeostasis. In the present study, we examined the changes of PPARgamma immunoreactivity and protein levels in the gerbil dentate gyrus (DG) after transient global cerebral ischemia using immunohistochemistry and western blot analysis. PPARgamma immunoreactivity was gradually increased from 1 day after ischemia-reperfusion. PPARgamma immunoreactivity, in accordance with protein level, was highest at 2 days after ischemia-reperfusion and was detected in microglia at this time. Thereafter, both PPARgamma immunoreactivity and protein level were decreased with time in the ischemic DG. These results indicate that PPARgamma may be related to the ischemia-induced microglial activation and neuronal damage/death in the DG after transient global cerebral ischemia.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imuno-Histoquímica / Isquemia Encefálica / Western Blotting / Gerbillinae / Microglia / Adipócitos / Giro Denteado / PPAR gama / Metabolismo dos Lipídeos / Glucose Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imuno-Histoquímica / Isquemia Encefálica / Western Blotting / Gerbillinae / Microglia / Adipócitos / Giro Denteado / PPAR gama / Metabolismo dos Lipídeos / Glucose Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2014 Tipo de documento: Artigo