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The Incidence of Serious Infection among Rheumatoid Arthritis Patients Exposed to Tumor Necrosis Factor Antagonists / 대한류마티스학회지
Article em Ko | WPRIM | ID: wpr-137464
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE: We wanted to investigate the incidence of serious infections among the rheumatoid arthritis (RA) patients who were treated with tumor necrosis factor alpha (TNF-alpha) antagonists. METHODS: We enrolled the 175 RA patients who were treated with TNF-alpha antagonists for at least 3 months during February 2003 to July 2008, and these patients were in the SMART-b cohort of Kangnam St. Mary's hospital. Patients were prescribed infliximab, etanercept or adalimumab. The data was retrospectively collected. RESULTS: The incidence of serious infections among the RA patients treated with TNF-alpha was significantly increased according to the survival analysis, as compared with that of those patient treated with conventional DMARDs (p<0.01). The most common serious infection was pneumonia. There was no significant difference in the incidence of serious infections among the three TNF-alpha antagonists used in this study (p=0.96). But the serious infections occurred more often in the patients who received more than 10 mg methotrexate (MTX) per week (p=0.02). CONCLUSION: RA patients treated with TNF-alpha antagonists had a higher incidence of serious infection. Therefore, close monitoring for serious infection is needed for RA patients who are receiving TNF-alpha antagonists.
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Texto completo: 1 Índice: WPRIM Assunto principal: Pneumonia / Artrite Reumatoide / Imunoglobulina G / Metotrexato / Incidência / Estudos Retrospectivos / Estudos de Coortes / Fator de Necrose Tumoral alfa / Receptores do Fator de Necrose Tumoral / Antirreumáticos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: Ko Revista: The Journal of the Korean Rheumatism Association Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Pneumonia / Artrite Reumatoide / Imunoglobulina G / Metotrexato / Incidência / Estudos Retrospectivos / Estudos de Coortes / Fator de Necrose Tumoral alfa / Receptores do Fator de Necrose Tumoral / Antirreumáticos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: Ko Revista: The Journal of the Korean Rheumatism Association Ano de publicação: 2010 Tipo de documento: Article