Rheumatoid Arthritis and microRNA / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 230-237, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-137469
ABSTRACT
MicroRNAs (miRNAs) are small, single-stranded, non-coding RNA molecules of 20~22 nucleotides, which are involved in many biologic functions such as development, cell proliferation, differentiation, and apoptosis. In addition to these biologic functions, recent reports have demonstrated that miRNAs play important roles in the development of the immune system and the regulation of immune responses. Dysregulation of miRNAs might be involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Recent studies have shown that miR-146a, miR-155, and miR-203 are overexpressed in RA and that miR-124a is under expressed in RA. miR-146 downregulates the expression of IL-1 receptor associated kinase 1 and TNF receptor-associated factor 6 involved in IL-1beta signaling, and miR-155 suppresses the expression of matrix metalloproteinases 1 and 3, suggesting that these miRNAs act as negative feedback regulators of inflammation and tissue damage in RA. In this report, we review the current knowledge about miRNAs and summarize the involvement of miRNAs in RA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfotransferases
/
Artrite Reumatoide
/
Doenças Autoimunes
/
Interleucina-1
/
Apoptose
/
Metaloproteinases da Matriz
/
RNA não Traduzido
/
MicroRNAs
/
Fator 6 Associado a Receptor de TNF
/
Proliferação de Células
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2010
Tipo de documento:
Artigo
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