Short-Term Effects of Ginkgo biloba Extract on Peripapillary Retinal Blood Flow in Normal Tension Glaucoma
Korean Journal of Ophthalmology
;
: 323-328, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-138085
ABSTRACT
PURPOSE:
Based on the vascular theory of glaucoma pathogenesis, we wanted to evaluate the effect of Ginkgo biloba extract (GBE) on peripapillary blood flow in patients with normal tension glaucoma (NTG).METHODS:
Thirty patients with NTG were randomly placed in the GBE-treated or control groups. The GBE-treated group received 80 mg GBE orally, twice a day for four weeks, and the control group received a placebo twice a day for four weeks. Complete ocular examinations including visual field, Heidelberg retina flowmeter, and systemic examinations were performed on the first study day and on the day treatment was completed.RESULTS:
After GBE treatment, the mean blood flow, volume, and velocity increased at almost all points, and there was a statistically significant increase in blood flow at almost all points, in comparison to the placebo. Blood volume significantly increased only in the superior nasal and superior temporal neuroretinal rim areas. GBE also significantly increased blood velocity in areas of the inferior temporal neuroretinal rim and superior temporal peripapillary area.CONCLUSIONS:
GBE administration appears to have desirable effect on ocular blood flow in NTG patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Disco Óptico
/
Fluxo Sanguíneo Regional
/
Retina
/
Fatores de Tempo
/
Extratos Vegetais
/
Campos Visuais
/
Método Duplo-Cego
/
Estudos Retrospectivos
/
Fluxometria por Laser-Doppler
/
Ginkgo biloba
Tipo de estudo:
Estudo observacional
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2011
Tipo de documento:
Artigo
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