Changes in High Levels of 17 alpha-Hydroxyprogesterone at Neonatal Screening / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 156-161, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-138144
ABSTRACT
PURPOSE:
There are some cases of false positive in neonatal screening for congenital adrenal hyperplasia. To understand its significance of the increased 17 alpha-hydroxyprogesterone(17 alpha-OHP) levels in the cases of positive result, we followed its levels during infancy.METHODS:
From July 1997 to June 1998, totally 1,730 babies were screened for congenital adrenal hyperplasia(CAH) measuring 17 alpha-hydroxyprogesterone(17 alpha- OHP) using an enzyme immunoassay(EIA) on dried blood spots. In infants of positive result, the radioimmunoassay(RIA) was used measuring 17 alpha-OHP in serum. And we followed up the levels of 17 alpha-OHP during infancy. Cortisol and ACTH were also measured and followed up in the morning simultaneously.RESULTS:
No CAH was detected during the study period. With the 13 ng/mL cutoff limit for 17 alpha-OHP before March 1998, the recall rate was 3.09%. With the 20 ng/mL cutoff limit after March 1998, the recall rate was decreased to 1.58%. Follow-up of the high levels of 17 alpha-OHP in positive cases showed a sharply decreased curve according to age.CONCLUSION:
In clinically normal neonates, the high levels of 17 alpha-OHP at screening decreased continuously during infancy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hidrocortisona
/
Programas de Rastreamento
/
Seguimentos
/
Triagem Neonatal
/
Hiperplasia Suprarrenal Congênita
/
Hormônio Adrenocorticotrópico
/
17-alfa-Hidroxiprogesterona
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Coreano
Revista:
Journal of Korean Society of Pediatric Endocrinology
Ano de publicação:
2003
Tipo de documento:
Artigo
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