Two Cases of Tuberous Sclerosis

ABSTRACT

Retinal hamartomas are usually found in more than half of patients with ocular involvement of tuberous sclerosis. Morphologically, the retinal hamartomas have been divided into three types type 1, the relatively flat, soft-appearing, and semitransparent lesions; type 2, elevated, nodular, and solid-appearing masses; and type 3, a combination of the two. In some instances, fundus contains a number of midpripheral depigmented lesions that appeared to be punched-out. The authors experienced two cases of tuberous sclerosis which consist of retinal hamartomas, skin lesions, and seizure. The first case was a 22-year-old man with all 3 types of retinal hamartomas and one punched-out lesion. The second case was a 19-year-old female with type 1 retinal hamartomas in both eyes. Retinal hamartomas showed varying degrees of diffuse fluorescein leakage according to the types from the capillaries within the tumors.