Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B
Clinics in Orthopedic Surgery
;
: 232-236, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-138559
ABSTRACT
In Fanconi syndrome, hypophosphatemic osteomalacia is caused by proximal renal tubule dysfunction which leads to impaired reabsorption of amino acids, glucose, urate, and phosphate. We present a rare case of a 43-year-old Korean male who was found to have insufficiency stress fracture of the femoral neck secondary to osteomalacia due to Fanconi syndrome. He had been receiving low-dose adefovir dipivoxil (ADV, 10 mg/day) for the treatment of chronic hepatitis B virus infection for 7 years and he subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction. The incomplete femoral neck fracture was fixed with multiple cannulated screws to prevent further displacement of the initial fracture. After cessation of ADV and correction of hypophosphatemia with oral phosphorus supplementation, the patient's clinical symptoms, such as bone pain, muscle weakness, and laboratory findings improved.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteomalacia
/
Fósforo
/
Ácido Úrico
/
Fraturas de Estresse
/
Hipofosfatemia
/
Hepatite B Crônica
/
Síndrome de Fanconi
/
Fraturas do Colo Femoral
/
Colo do Fêmur
/
Mialgia
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics in Orthopedic Surgery
Ano de publicação:
2016
Tipo de documento:
Artigo
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