Cerebral Palsy due to Intracranial Hemorrhage Caused by Consumptive Coagulopathy in Protein C Deficiency: A Case Report / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 44-47, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-139262
ABSTRACT
Protein C (PROC) is a potent anticoagulant inactivating coagulation factors Va and VIIIa. PROC deficiency is very rare condition inherited as an autosomal dominant or recessive trait, and associated with various thromboembolic and ischemic conditions. Moreover, severe form of PROC deficiency can cause fatal hemorrhagic complications due to consumptive coagulopathy. We reported two children with hemorrhagic stroke who were diagnosed as severe PROC deficiency caused by two different types of compound heterozygous PROC gene mutations. We described results of laboratory tests, genetic analysis, brain magnetic resonance images, and functional outcomes. Both children received prophylactic anticoagulation therapy and presented with purple-colored skin lesions during rehabilitation. Purpura fulminans caused by insufficient anticoagulation should be differentiated from hematoma caused by excessive anticoagulation therapy in these children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reabilitação
/
Pele
/
Encéfalo
/
Fatores de Coagulação Sanguínea
/
Proteína C
/
Paralisia Cerebral
/
Deficiência de Proteína C
/
Acidente Vascular Cerebral
/
Hemorragias Intracranianas
/
Púrpura Fulminante
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2017
Tipo de documento:
Artigo
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