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Clinical Features and Natural Course of Benign Transient Hyperphosphatasemia in Children / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition ; : 173-178, 2007.
Artigo em Coreano | WPRIM | ID: wpr-139410
ABSTRACT

PURPOSE:

This study was conducted to analyze the clinical manifestation and natural course of benign transient hyperphosphatasemia (BTH) in children.

METHODS:

A total of 17 children diagnosed with BTH between June 2006 and July 2007, were included in this study. Clinical records and laboratory tests were analyzed retrospectively for all children.

RESULTS:

The mean age of the patients was 26.9+/-13.8 months (range 9 to 49 months). Nine of the 17 BTH cases (52.9%) occurred in patients that had previously suffered from infectious diseases. While the patients were suffering from BTH, the mean serum level of alkaline phosphatase (ALP) was 2,500.2+/-1,165.1 U/L, however, these elevated serum ALP levels normalized within 7 weeks of recovery in all cases. In addition, a seasonal peak in the onset of BTH was observed from September to December. Further, the measurement of ALP isoenzymes in 7 of the patients with BTH, revealed a marked elevation of bone fraction.

CONCLUSION:

It is important for pediatricians to understand the clinical manifestation and benign course of BTH to avoid unnecessary diagnostic evaluation in children showing a transient increase in ALP activities.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estações do Ano / Doenças Transmissíveis / Estudos Retrospectivos / Fosfatase Alcalina / Isoenzimas Tipo de estudo: Estudo observacional Limite: Criança / Humanos Idioma: Coreano Revista: Korean Journal of Pediatric Gastroenterology and Nutrition Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estações do Ano / Doenças Transmissíveis / Estudos Retrospectivos / Fosfatase Alcalina / Isoenzimas Tipo de estudo: Estudo observacional Limite: Criança / Humanos Idioma: Coreano Revista: Korean Journal of Pediatric Gastroenterology and Nutrition Ano de publicação: 2007 Tipo de documento: Artigo