Risk Factors of Recurrence after Gross Total Excision in Pediatric Craniopharyngioma
Journal of Korean Neurosurgical Society
;
: 20-25, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-13972
ABSTRACT
OBJECTIVES:
A substantial number of craniopharyngiomas recur despite gross total excision. The purpose of our study was to investigate pattern of recurrence and to verify prognostic factors for recurrence after gross total excision of craniopharyngiomas in children.METHODS:
A series of 36 patients with craniopharyngiomas were reviewed. All patients had undergone gross total excision and none of them received radiotherapy after initial surgery. Fifteen were girls and twenty-one were boys, with a mean age of 7.3 years(range, one to 15 years). The mean follow-up period was 52 months(range, one to 149 months). Recurrence was noted in 14 patients within 83 months(mean 31.4 months).RESULTS:
The overall three-year recurrence free survival rate was 65%, and the five-year recurrence-free survival rate was 55%. Regular neuroimaging follow-up at six to 12-month intervals detected tumor recurrence of a smaller size before symptoms developed(p<0.05). At the first surgical procedure, the optic nerve/chiasm(n=23) was the most common adhesion site. The most frequent sites of recurrence were the optic nerve/chiasm(n=6) and the pitiutary fossa(n=6). Tumor location was the single significant clinical predictor of recurrence. The five-year recurrence-free survival rate was 39% for those who had an intrasellar tumor component and 81% for those who did not (p<0.05).CONCLUSION:
Craniopharyngiomas with intrasellar components should be followed cautiously and regular follow-up of patients should be emphasized, even when the tumors are totally resected.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Radioterapia
/
Recidiva
/
Taxa de Sobrevida
/
Fatores de Risco
/
Seguimentos
/
Craniofaringioma
/
Neuroimagem
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2001
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS