The Role of Basic Fibroblast Growth Factor in Moyamoya Disease
Journal of Korean Neurosurgical Society
;
: 5-11, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-13974
ABSTRACT
OBJECTIVES AND OMPORTANCE The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. METHODS:
The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation.RESULTS:
The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted.CONCLUSIONS:
The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ensaio de Imunoadsorção Enzimática
/
Fator 2 de Crescimento de Fibroblastos
/
Fibroblastos
/
Doença de Moyamoya
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2001
Tipo de documento:
Artigo
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