Clinical Implication of Galectin-1 Expression in Human Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
; : 36-40, 2006.
Article
em Ko
| WPRIM
| ID: wpr-140337
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The role of different galectins in the pathogenesis of different types of malignancy is now being intensely investigated. In this study, authors investigated the level of galectin-1 expression in human breast cancer tissue to define its relationship to the tumor invasiveness and tumor progression. METHODS: Formalin-fixed, paraffin-embedded tissues from 79 randomly selected breast cancer patients were used to perform immunohistochemical staining for galectin-1. The primary antibody was diluted mouse monoclonal antibody against galectin-1. The staining results were then interpreted by an experienced pathologist, and the results were compared between the groups having different pathologic variables. RESULTS: In breast cancer patients, galectin-1 was diversely expressed in the cancer tissue. Galectin-1 was expressed in both cancer cells and cancer-associated stromal cells. The levels of galectin-1 expression in cancer-associated stromal cells were higher in patients with invasive carcinoma (p = 0.001), in patients with advanced T stages (p = 0.007), and in patients with advanced TNM stages (p = 0.007). The galectin-1 expression in cancer-associated stromal cells was also higher in patients with lymph node metastasis and advanced N stages, but did not reach a statistically significant level. The galectin-1 expression in cancer cell did not have any correlation with pathologic variables. CONCLUSION: This is the first study that has demonstrated the relationship of galectin-1 expression with the tumor invasiveness and tumor progression in human breast cancer. Further large-scaled studies are needed to define the prognostic value of galectin-1 in breast cancer patients, and the exact role of galectin-1 should be investigated more thoroughly.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Mama
/
Neoplasias da Mama
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Imuno-Histoquímica
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Células Estromais
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Galectinas
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Galectina 1
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Linfonodos
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Invasividade Neoplásica
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Metástase Neoplásica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
Ko
Revista:
Journal of Breast Cancer
Ano de publicação:
2006
Tipo de documento:
Article