Nonmyeloablative stem cell transplantation / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 11-27, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-140525
ABSTRACT
Allogenic hematopoietic stem cell transplantation is one of the effective therapy for several hematologic malignancies. Transplantation preparative regimen is designed to eradicate the patient's underlying disease and immunosuppress the patient adequately to prevent rejection of donor's hematopoietic stem cells. so, Conventional myeloablative preparative regimens with high-dose chemotherapy or radiotherapy are related to high rate of morbidity and mortality. however, It has become clear that the high-dose therapy dose not eradicate the malignancy in some patients, and that the therapeutic benefit of allogenic transplantation is largely related to graft-versus-leukemia/graft-versus-tumor (GVL/GVT) effect. An new approach is to utilize less toxic, nonmyeloablative preparative regimens to achieve engraftment and allow GVL/GVT effects to developed. This strategy reduces the risk of treatment-related mortality and allows transplantation for elderly and those with comorbidities that preclude high-dose chemoradiotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Radioterapia
/
Células-Tronco
/
Células-Tronco Hematopoéticas
/
Comorbidade
/
Mortalidade
/
Transplante de Células-Tronco Hematopoéticas
/
Neoplasias Hematológicas
/
Transplante de Células-Tronco
/
Tratamento Farmacológico
/
Quimiorradioterapia
Tipo de estudo:
Estudo prognóstico
Limite:
Idoso
/
Humanos
Idioma:
Coreano
Revista:
Yeungnam University Journal of Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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