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A Study for The Effects of UV exposure and UV Exposure After Being Applied by Sunscreens on Hepatic Microsomal Cytochrome Enzyme System and Vitamin D in Newborn Rats / 대한피부과학회지
Korean Journal of Dermatology ; : 205-212, 1986.
Artigo em Coreano | WPRIM | ID: wpr-14088
ABSTRACT
We observe changes of activation of hepatic microsomal cytochrome p-450, changes of formation of riug-and N-hydroxylation of 2-acetylaminofluorene, and changes of vitamin D, in the liver which exposed to UV light and expoeed to UV light after being applied by sunscreens. The results of our study are as shown below 1. The contents of hepatic microsomal cytochrome p-45p of newborn rats were found to be remarkably increase in the group exposed to UV light for 3 weeks (p<0. 001), but such changes were much reduced in the group exposed to UV light for 3 weeks after being applied by sunscreens(p<0.05. p<0.001, ) 2.Cytochrome p-450 induced by UV light was found to be significantly increased ring and N-hydroxylation of 2-acetylarninofluorene known as carcinogenic source for the liver. In the group exposed to UV light for 3 weeks after being applied by sunscreens, both of ring-and N-hydroxylation of 2-acetylaminofluorene were significantly reduced(p<0. 0, p<0. 001). 3, The contents of vitarnin D, in the liver of newborn rats were found to be gradually increased when they were exposed to UV light for 1 week or 3 weeks (p<0. 001), and in the group exposed to UV light after being applied by sunscreens, such changes were reduced remarkably(pg0. (301).
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: 2-Acetilaminofluoreno / Protetores Solares / Raios Ultravioleta / Vitamina D / Vitaminas / Colecalciferol / Sistema Enzimático do Citocromo P-450 / Citocromos / Fígado Limite: Animais / Humanos Idioma: Coreano Revista: Korean Journal of Dermatology Ano de publicação: 1986 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: 2-Acetilaminofluoreno / Protetores Solares / Raios Ultravioleta / Vitamina D / Vitaminas / Colecalciferol / Sistema Enzimático do Citocromo P-450 / Citocromos / Fígado Limite: Animais / Humanos Idioma: Coreano Revista: Korean Journal of Dermatology Ano de publicação: 1986 Tipo de documento: Artigo