Effects of Drugs on the Interaction of Calcium and Cardiac Muscle Memberane Fragments
Yonsei Medical Journal
;
: 1-7, 1982.
Artigo
em Inglês
| WPRIM
| ID: wpr-141037
ABSTRACT
The effect of drugs on calcium-binding to cardiac muscle membrane fragments and its turnover rate was studied. Ouabian, acetylcholine, isoproterenol and norepinephrine did not have any effect either on calcium-binding to membrane fragments or an washout ahnd release curves of previously bound calcium. Local anesthetics inhibited the calcium-binding. Tetracaine at concentrations of 1 and 10 mM inhibited the calcium-binding by 30% and 54%, respectively, while 10 mM lidocaine inhibited it by 17%. Propranolol, a well-known adrenergic beta-blocker, also inhibited calcium-binding at the external calcium concentration of 10(-3) M. This effect of propranolol may be attributed to its local anesthetic-like action, rather than to the adrenergic blocking effect.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Técnicas In Vitro
/
Cardiotônicos
/
Membrana Celular
/
Cálcio
/
Anestésicos Locais
/
Animais
/
Miocárdio
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1982
Tipo de documento:
Artigo
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